Glycosylasparaginase Inhibition Studies: Competitive Inhibitors, Transition State Mimics, Noncompetitive Inhibitors
نویسندگان
چکیده
منابع مشابه
Molecular Electrostatic Potential Analysis for Enzymatic Substrates, Competitive Inhibitors, and Transition-State Inhibitors
Recent advances in the application of kinetic isotope effects to enzyme-catalyzed reactions have provided reliable information for enzymatic transition state structures. A method is presented for quantifying the similarity of substrates and inhibitors with their enzyme-stabilized transition states. On the basis of transition-state stabilization theory for enzymatic reactions, molecules most sim...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition
سال: 2001
ISSN: 8755-5093
DOI: 10.1080/14756360109162375